Single Gene Test

OncoCEPT Solid

(CEPT: Comprehensive Evaluation for Personalized Treatment)

Cancer is disease of the genome. Changes in genome or mutations lead to uncontrolled growth of cells and hence into tumors. While cancers are characterized by numerous genomic aberrations, some of these somatic mutations, known as
driver mutations, induce growth and impaired differentiation leading to cancer development. Various consortia such as The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (CGC) and such have sorted and identified driver
mutations in various different cancers, based on studies of thousands of tumor tissues. Various targeted therapies are developed against the specific mutations that drive the cancer tumor.

OncocEPT Solid identifies these driver mutations and helps in identifying targeted therapies, prognosis and clinical trials applicable to the patient.

Prominent technical features of OncoCEPT Solid:

TAT: 12 Working Days

OncoCEPT Solid Comprehensive:

(CEPT: Comprehensive Evaluation for Personalized Treatment)

Tumorigenesis in humans is a multistep process and that these steps reflect genetic alterations that drive the progressive transformation of normal human cells into highly malignant derivatives. Cancer treatment decisions are increasingly made on the basis of genomic information contained in the genes. OncoCEPT Solid Comprehensive test detects various multiple relevant biomarkers in a single next-generation sequencing (NGS) test by focusing on precision oncology.

OncocEPT Solid identifies these driver mutations and helps in identifying targeted therapies, prognosis and clinical trials applicable to the patient.

Prominent technical features of OncoCEPT Solid Comprehensive are:

TAT: 15 Working Days

OncoCEPT Liquid:

(CEPT: Comprehensive Evaluation for Personalized Treatment)

Cancer leads to formation of tumor. However, obtaining a tissue sample could be challenging. This leads to limiting amounts of tumor tissue being collected which is expected to be used for multiple and different types of investigations.
Often the investigations can’t be done due to the lack of sample. This test is noninvasive and cost-effective alternative to traditional biopsy samples, especially in lung and breast cancers.

Cancer also evolves Over time. Cancer may relapse after treatment of primary tumor. This relapse occurs due to change its genome. OncoCEPT Liquid can give snapshots of evolving cancer genome when the test is performed at period intervals. This information can help the oncologist pre-empt and modify treatment regimen.

Prominent technical features of OncoCEPT Liquid:

TAT: 12 Working Days

Microsatellite instability (MSI):

In normal cells, the DNA mismatch repair (MMR) system recognizes and repairs genetic mismatches generated during DNA replication. A deficient MMR (dMMR) system results in the persistence of DNA mismatches in microsatellites that may then be incorporated into the genetic code as mutations which is sporadic in nature. Tumors that are deficient of DNA mismatch repair (MMR) system are designated as MSI-high and the once with intact MMR are called MSI-stable. Pembrolizumab is indicated for the treatment of adult and pediatric patients with unresectable or metastatic microsatellite instability-high (MSI-H). These tumors are (1) Solid tumors that have progressed following prior treatment and who have no satisfactony alternative treatment options, or (2) colorectal cancer that has progressed following treatment with fluoropyrimidine, oxaliplatin, and irinotecan.

Prominent technical features of MSl test:

TAT: 7 Working Days

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Accreditations

The above accreditations have been granted to NEUBERG SUPRATECH REFERENCE LABORATORIES PRIVATE LIMITED (NSRL). The Neuberg Center for Genomic Medicine (NCGM) is affiliated to NSRL.