FISH

Fluorescence In Situ Hybridisation(FISH) is a fluorescent probe based laboratory technique used for detection of specific DNA sequences on a chromosome. Probes complementary to the region of interest are used to detect presence or absence of that region. This helps in identifying chromosomal abnormality present in cancer and also other chromosomal disorders. It can identify genetic alterations which are too small to be seen on Karyotyping. It has an added advantage that it can performed on cells irrespective of their cell cycle phase, resulting into a much shorter turnaround time than other standard tests.